Plácido was born in Mexico City, son of tenor and philanthropist Plácido Domingo. From an early age he was exposed to the operatic world and developed his great passion for music.

He has written songs for artists like Michael Bolton, Riccardo Cocciante, Vanessa Williams, Sarah Brightman, Jose Carreras, Luciano Pavarotti, Leona Mitchell, Diana Ross, Alejandro Fernández, Tony Bennett, and Plácido Domingo.

He participated in the album Amore Infinito (released 2009) as executive producer, composer and singer. The album included verses by Pope John Paul II, performed by his father, which reached the top chart on Billboard Magazine’s Top Classical Crossover Albums.

In 2010, together with SonicProjects Records, Plácido made his international debut as a performer, collaborating with Grammy award winner producer/engineer Juan Cristóbal Losada, with whom he created a Christmas EP called Songs for Christmas/Canciones de Navidad. The EP was released on November 9, 2010, one day before his worldwide debut at the “Person of the Year” ceremony at the Latin Grammy Awards of 2010. It includes a never before released Spanish adaptation by Plácido and Juan Cristóbal Losada of “My Grown-Up Christmas List” by David Foster and Linda Thompson, and a new version of the Puerto Rican Christmas classic “Villancico Yaucano”.

In 2012, Plácido released his first full-length album, containing new Spanish and English versions of classic songs from the ʻ50s and ʻ60s like Bésame Mucho/Kiss Me Much, Solamente Una Vez/You Belong To My Heart and Sabor A Mi/Be True To Me, made famous by artists like Nat King Cole, Frank Sinatra and Dean Martin. It is going to be a classical crossover album with influences from all across the Americas, containing tango, swing, big band, cha cha cha, and even bachata influences. The album further includes features by Arturo Sandoval, Plácido Domingo and Black Violin, and many others.

2018 saw Placido’s world premiere of his musical “Vlad” (the history of a vampire) in Spain which was enthusiastically acclaimed by the audience and press alike.